Tribbles 3 deficiency promotes atherosclerotic fibrous cap thickening and macrophage-mediated extracellular matrix remodelling
Tribbles 3 (TRIB3) modulates lipid and glucose metabolism, macrophage lipid uptake, with a gain-of-function variant associated with increased cardiovascular risk.Here we set out to examine the role of this pseudokinase in atherosclerotic plaque development.Human endarterectomy atherosclerotic tissue specimens analysed by immunofluorescence showed u