TRIBBLES 3 DEFICIENCY PROMOTES ATHEROSCLEROTIC FIBROUS CAP THICKENING AND MACROPHAGE-MEDIATED EXTRACELLULAR MATRIX REMODELLING

Tribbles 3 deficiency promotes atherosclerotic fibrous cap thickening and macrophage-mediated extracellular matrix remodelling

Tribbles 3 (TRIB3) modulates lipid and glucose metabolism, macrophage lipid uptake, with a gain-of-function variant associated with increased cardiovascular risk.Here we set out to examine the role of this pseudokinase in atherosclerotic plaque development.Human endarterectomy atherosclerotic tissue specimens analysed by immunofluorescence showed u

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QTG-Finder: A Machine-Learning Based Algorithm To Prioritize Causal Genes of Quantitative Trait Loci in Arabidopsis and Rice

Linkage mapping is one of the most commonly used methods to identify genetic loci that laguna 3hp dust collector determine a trait.However, the loci identified by linkage mapping may contain hundreds of candidate genes and require a time-consuming and labor-intensive fine mapping process to find the causal gene controlling the trait.With the availa

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Three-dimensional tomographic reconstruction of atmospheric gravity waves in the mesosphere and lower thermosphere (MLT)

Gravity waves (GWs) have been intensively studied over recent decades because of their dominant role in the dynamics of the mesosphere and lower thermosphere (MLT).The momentum deposition caused by breaking GWs determines the basic structure and drives the large-scale circulation in the MLT.Satellite observations provide a way to qualify the proper

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SOEHARTO AND THE POLITICIZATION OF INDONESIAN ISLAM (1968-1998)

Soeharto treated Indonesian Muslim Communities with two different ways.On the one side, he has given whole wheat phyllo dough them full freedom to conduct Islamic rituals such as prayers, almsgivings, fasting during Ramadhan, pilgrim and so on.On the other side, however, he has not given them full freedom to exercise politics at the practical level

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Pleiotropy constrains the evolution of protein but not regulatory sequences in a transcription regulatory network influencing complex social behaviours

It is increasingly apparent that genes and networks that influence complex behaviour are evolutionary conserved, which is paradoxical considering that behaviour is socksmith santa cruz labile over evolutionary timescales.How does adaptive change in behaviour arise if behaviour is controlled by conserved, pleiotropic, and likely evolutionary constra

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